![]() The immune response occurred throughout the body, not simply in the area where the histotripsy was applied. Image credit: Marcin Szczepanski/Lead Multimedia Storyteller, Michigan Engineering Zhen Xu,Professor of Biomedical Engineering at the University of Michigan (left) and Tejaswi Worlikar, Biomedical Engineering PhD student discuss the 700kHz, 260-element histotripsy ultrasound array transducer they use in Prof. In contrast, sound waves kill the cancer cells by breaking their cell walls, releasing tumor antigens that then trigger the body’s defense systems. When cells die by chemotherapy or radiation, these antigens are destroyed in the process. The key turned out to be tumor antigens-proteins only found in cancer cells and hidden behind their cell walls. Gardner Child Professor of Surgery and vice chair of surgery, whose lab designed immune study protocols and measured immune responses for the study published this month in Frontiers in Immunology. “We found that histotripsy somehow not only kills cancer cells, but causes them to undergo a unique pathway of cell death that draws the attention of the immune system,” said Clifford Cho, the C. The immune response also prevented further spread, with no evidence of recurrence or metastases in more than 80% of the animals. ![]() A study from last spring showed that histotripsy breaks down liver tumors in rats, leading to the complete disappearance of the tumor even when sound waves are applied to only 50% to 75% of the mass. Until now, researchers didn’t understand how histotripsy was activating the immune system. Zhen Xu,Professor of Biomedical Engineering at the University of Michigan works in her office. It could potentially offer medical professionals a treatment option for patients without the harmful side effects of radiation and chemotherapy. ![]() The technique developed at Michigan, known as histotripsy, offers a two-prong approach to attacking cancers: the physical destruction of tumors via sound waves and the kickstarting of the body’s immune response. By breaking down the cell wall “cloak,” the treatment exposes cancer cell markers that had previously been hidden from the body’s defenses, researchers at the University of Michigan have shown. When noninvasive sound waves break apart tumors, they trigger an immune response in mice. Study: Spatiotemporal local and abscopal cell death and immune responses to histotripsy focused ultrasound tumor ablation The 700kHz, 260-element histotripsy ultrasound array transducer used in Prof.
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